This trial has completed recruitment on this platform, and is no longer accepting new referrals.
A vaccine trial for COVID-19
A study to test an investigational vaccine that may protect people from getting sick if they come
into contact with the SARS-CoV-2 virus, which causes COVID-19; also known as coronavirus.
Moderna’s Commitment to Diversity & Inclusion
Moderna is committed to researching a safe and effective vaccine that protects people from all backgrounds against COVID-19.
People from racial and ethnic minority groups are at even greater risk of getting sick and dying from COVID-19.
Given that certain populations can respond differently to medical therapies, it is important that study volunteers
from all races and ethnicities participate in the COVE Study to ensure the vaccine is safe and effective for everyone to use.
Moderna has proudly partnered with 99 clinical research sites across the US, and we actively collaborate with nonprofits,
local community organizations, and faith and cultural leaders to address current and historical barriers, build trust,
and raise awareness of this important clinical trial to communities at highest risk of COVID-19.
The mRNA-1273 vaccine is being developed to prevent COVID-19, the disease resulting
from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection. Study
volunteers will participate and be followed by medical staff for up to two years.
The study doctor and medical staff will talk to you about additional medical support
that you will receive if you experience COVID-19 symptoms at any time while in this
clinical trial. Insurance is not needed to join this clinical trial, and compensation
for your time will be available.
Given that certain populations can respond differently to medical therapies, it is extremely important that
this clinical trial include people from all races and ethnicities to ensure the vaccine is safe and effective
for everyone to use.
Be 18 years of age and older
Have never tested positive for COVID-19
Have a greater chance of becoming infected with COVID-19. Examples include:
Living in crowded conditions such as shared housing
Working in close contact with the public or other workers including “essential work” settings: healthcare facilities, farms, factories, grocery stores, restaurants, daycares, and public safety/transportation
You have underlying medical conditions
You are 65 or older
Participants must not:
Have been in close contact with anyone that has tested positive for COVID-19 in the past month
Be pregnant or breastfeeding
Have participated in another trial in the past month
Commitments from you
The total length of trial participation is two years and includes seven visits to the study clinic and
monthly phone calls from the study doctor.
Study volunteers will be given two injections in the upper arm – one month apart. Each study volunteer
has a 50% chance of receiving the mRNA-1273 study vaccine and a 50% chance of receiving the placebo (like flipping a coin).
Study volunteers will come back to the research clinic four more times within the next 12 months.
Study Volunteers will get a call from the study doctor after each injection, and then monthly after
that to monitor for COVID-19 symptoms. During these phone calls, the study doctor and medical staff will
check how each study volunteer is feeling and ask for updates on their health.
Study volunteers are given a hand-held electronic diary (similar to an iPhone) and will also be asked to
complete weekly entries about any COVID-19 symptoms for the duration of the COVE Study.
Study volunteers will have their final visit to the research clinic about two years from the date of their second injection.
You will need to travel to one of the 100 sites taking part in this clinical trial. Sites are located in:
Peoria, Arizona, US
Stockbridge, Georgia, US
Chandler, Arizona, US
Birmingham, Alabama, US
Phoenix, Arizona, US
Glendale, Arizona, US
Atlanta, Georgia, US
Jacksonville, Florida, US
Newton, Kansas, US
La Mesa, California, US
Boston, Massachusetts, US
Colorado Springs, Colorado, US
Tucson, Arizona, US
Oklahoma City, Oklahoma, US
Little Rock, Arkansas, US
Los Angeles, California, US
Sacramento, California, US
Banning, California, US
Saint Louis, Missouri, US
Rockville, Maryland, US
Omaha, Nebraska, US
Redding, California, US
New York, New York, US
Baton Rouge, Louisiana, US
Grand Island, Nebraska, US
Cincinnati, Ohio, US
Charlotte, North Carolina, US
Melbourne, Florida, US
Norfolk, Nebraska, US
Miami, Florida, US
West Palm Beach, Florida, US
Petal, Mississippi, US
Tomball, Texas, US
Salt Lake City, Utah, US
Laredo, Texas, US
Medford, Oregon, US
Nashville, Tennessee, US
Houston, Texas, US
Philadelphia, Pennsylvania, US
Anderson, South Carolina, US
Fort Worth, Texas, US
Galveston, Texas, US
McAllen, Texas, US
Austin, Texas, US
Hollywood, Florida, US
Greenville, South Carolina, US
Baltimore, Maryland, US
Newark, New Jersey, US
Binghamton, New York, US
Metairie, Louisiana, US
Orlando, Florida, US
Chicago, Illinois, US
Spartanburg, South Carolina, US
Wichita, Kansas, US
Aurora, Colorado, US
Winston-Salem, North Carolina, US
Chapel Hill, North Carolina, US
Washington, District of Columbia, US
Hackensack, New Jersey, US
Knoxville, Tennessee, US
Dakota Dunes, South Dakota, US
(Not yet recruiting) Atlanta, Georgia, US
(Active not recruiting) La Jolla, California, US
(Not yet recruiting) Decatur, Georgia, US
(Not yet recruiting) Detroit, Michigan, US
(Active not recruiting) Fayetteville, North Carolina, US
(Active not recruiting) Las Vegas, Nevada, US
(Active not recruiting) Wilmington, North Carolina, US
(Active not recruiting) Cleveland, Ohio, US
(Active not recruiting) Rockville, Maryland, US
(Active not recruiting) Miami, Florida, US
(Not yet recruiting) San Antonio, Texas, US
(Not yet recruiting) Dallas, Texas, US
(Not yet recruiting) San Angelo, Texas, US
(Not yet recruiting) Chattanooga, Tennessee, US
(Active not recruiting) Pittsburgh, Pennsylvania, US
(Not yet recruiting) Mount Pleasant, South Carolina, US
(Active not recruiting) Raleigh, North Carolina, US
(Active not recruiting) Austin, Texas, US
(Active not recruiting) DeLand, Florida, US
(Active not recruiting) Lenexa, Kansas, US
(Active not recruiting) Chicago, Illinois, US
(Active not recruiting) Savannah, Georgia, US
(Active not recruiting) San Diego, California, US
The study vaccine is investigational as effectiveness and safety have not been established. There is no guarantee that the study vaccine will become commercially available.
Contribute to a potential solution that could solve a global health crisis.
Close monitoring and support by the study staff.
The investigational vaccine may cause serious
side effects or be uncomfortable.
The investigational vaccine may not work.
You might receive the placebo.
Participation in this clinical trial could inconvenience you. For example, you will need to travel to the study site
several times over a two-year period.
There may be unknown side effects of the investigational vaccine (short and long term).