Let us be the generation that stands up to cytomegalovirus (CMV), a highly contagious viral infection that can harm an unborn child. Learn more about a clinical trial for a potential vaccine.
This clinical trial is sponsored by Moderna. Moderna is studying mRNA-1647, an investigational
vaccine to understand whether it can help your immune system protect against cytomegalovirus (CMV).
The purpose of this clinical trial is to:
Evaluate the safety and efficacy of investigational vaccine (a vaccine not yet approved by a country's drug regulatory agency) mRNA-1647 against CMV
Evaluate the safety of the vaccine in women who test positive to prior exposure to CMV
What is CMV?
Cytomegalovirus, shortened to CMV, is a leading cause of birth defects around the world. CMV is a common viral infection that usually goes unnoticed or only causes mild symptoms in most people. But if a woman becomes infected with CMV while she is pregnant, she can pass the infection to her unborn baby. This can cause her child to suffer long-term disability due to birth defects, including hearing loss, or even death in very severe cases. Currently, there is no approved vaccine against CMV.
CMV is the #1
infection that causes
birth defects in the
U.S. and one of the
most common
infectious causes of
birth defects globally.
How Participation Works
The total length of participation in this clinical trial is approximately 2½ years (30 months).
Clinical trial volunteers will have a screening visit to check whether they are eligible to participate. The visit includes a wellness exam, review of your medical history, a urine pregnancy test, and some blood tests.
During the first 7 months, trial participants will attend 5 in-person visits, including 3 vaccination visits when they'll receive injections in the upper arm.
During the follow-up portion of the trial (Month 8 through Month 30), participants will have in-person visits every 3 months and will provide updates via an eDiary, may be contacted by telephone, or may be requested to come in for unscheduled visits in between such visits.
Each participant has a 50% chance of receiving the investigational vaccine and a 50% chance of receiving a placebo—like flipping a coin.
You will be compensated for your time and for each visit you complete. More information about
reimbursement can be found in the expenses section of the Patient Information and Informed Consent Form,
and your clinical trial team can also give you more details.
We will schedule your visits in a way that minimizes disruption to your work and other commitments.
Get to Know the Investigational Vaccine: mRNA-1647
The investigational vaccine may help the body's immune system recognize and protect itself if it comes into contact with CMV in the future. You cannot become infected with CMV from receiving the investigational vaccine. The investigational vaccine in this trial, mRNA-1647, is a newer type of vaccine known as an mRNA vaccine.
Map: Every virus has signature features on its surface that can trigger your immune
system. Once the features are mapped, an mRNA vaccine provides the blueprint to create the defense that
can help your body protect itself if it encounters the virus.
Read: Once your body has the blueprint, it knows exactly what to do. It reads mRNA
strands to build a defense by producing antibody proteins that are a lot like the answer key to a test.
This means the next time your immune system encounters this type of virus, it already has the answer to
help protect you.
Neutralize: Your body now knows how to neutralize the virus and is able to defend
itself against the threat if it encounters the virus in the future. The message from the blueprint that
was read is retained and recalled when needed. It's like remembering the answer from an old test without
having to re-learn the material.
Activate: Moderna is developing mRNA vaccines, like the investigational vaccine
mRNA-1647, that deliver blueprints to create the proteins that help activate immune responses against
a variety of viruses.
Get to Know the Investigational Vaccine: mRNA-1647
The investigational vaccine may help the body's immune system recognize and protect itself if it comes into contact with CMV in the future. You cannot become infected with CMV from receiving the investigational vaccine. The investigational vaccine in this trial, mRNA-1647, is a newer type of vaccine known as an mRNA vaccine.
Map: Every virus has signature features on its surface that can trigger your immune
system. Once the features are mapped, an mRNA vaccine provides the blueprint to create the defense that
can help your body protect itself if it encounters the virus.
Read: Once your body has the blueprint, it knows exactly what to do. It reads mRNA
strands to build a defense by producing antibody proteins that are a lot like the answer key to a test.
This means the next time your immune system encounters this type of virus, it already has the answer to
help protect you.
Neutralize: Your body now knows how to neutralize the virus and is able to defend
itself against the threat if it encounters the virus in the future. The message from the blueprint that
was read is retained and recalled when needed. It's like remembering the answer from an old test without
having to re-learn the material.
Activate: Moderna is developing mRNA vaccines, like the investigational vaccine
mRNA-1647, that deliver blueprints to create the proteins that help activate immune responses against
a variety of viruses.
About Clinical Trials
Vaccines aim to safely protect people against infections, and clinical trials are vital to creating vaccines. A clinical Trial can help researchers understand whether an investigational vaccine is safe and effective. By participating in the CMVictory Trial, you can help create a future where we may hopefully declare victory and prevent the spread of CMV.
Moderna is committed to keeping people at the center of everything we do as we continue to explore what is possible through mRNA science. Without people like you, researching potential new treatments and mRNA vaccines would not be possible.
We are proud to partner with the following groups and organizations in the fight for victory against CMV:
Who May Take Part
This clinical trial is looking for volunteers. To join this clinical trial, you must be:
A woman between 16-40 years of age
In good health
In close contact with at least one child 5 years of age or younger for at least 8 hours a week, if age 20 or older
Not pregnant or planning on becoming pregnant within the next 9 months
Clinical trial staff will explain any additional requirements and answer any questions you or a loved one may have about participation. You may stop participation in the clinical trial at any time, and you do not have to give a reason for doing so.
Diseases do not discriminate— and neither should clinical trials.
Moderna is committed to researching safe and effective mRNA-based vaccines and therapies to bring better health and living to people of all ages, sexes, and backgrounds.
The CMVictory Trial will take place at locations (or sites) all around the world. Use this site locator to search for the site closest to you—as well as their contact information.
Find a location near you.
NHS Foundation Trust - Newcastle Newcastle, United Kingdom NE1 4LP
SEC Clinical Research LLC - Dothan - ClinEdge Dothan, Alabama United States 36305
Lakeview Clinical Research Guntersville, Alabama United States 35976-2206
Accel Research Site - Achieve - Birmingham Birmingham, Alabama United States 35216
Central Research Associates Inc Birmingham, Alabama United States 35205-1605
Applied Research Center of Arkansas Little Rock , AR United States 72212
Hope Research Institute LLC - Hunt - Tempe Tempe, Arizona United States 85284
Epic Medical Research Arizona - Surprise Surprise, Arizona United States 85378
The Institute for Liver Health - Tucson Tucson, Arizona United States 85712
Noble Clinical Research - Tuscon Tucson, Arizona United States 85704
Hope Research Institute LLC - Hunt - Phoenix Phoenix, Arizona United States 85018
Chandler Clinical Trials, LLC Chandler, Arizona United States 85224
Preferred Research Partners - Little Rock Little Rock, Arkansas United States 72211
Arizona Clinical Trials Messa, AZ United States 85210
Carbon Health- NoHo West Urgent Care and Primary Care North Hollywood, California United States 91606
Women’s Healthcare Research San Diego, California United States 92111
Standford Center for Clinical Research Stanford, California United States 94305
Empire Clinical Research Pomona, California United States 91767-1800
Bayview Research Group - Valley Village Valley Village, California United States 91607
Long Beach Research Institute, LLC Long Beach, California United States 90805
Apex Research Group - Fair Oaks Fair Oaks, California United States 95628
Northern California Research Corp Sacramento, California United States 95821-2640
Catalina Research Institute - Montclair Montclair, California United States 91763
Care Access Research - Santa Clarita Santa Clarita, California United States 91321
Next Level Clinical Trials West Covina, California United States 91790
Paradigm Clinical Research Institute - La Mesa La Mesa, California United States 91942
Velocity Clinical Research - Chula Vista Chula Vista, California United States 91911
Smart Cures Clinical Research - Anaheim Anaheim, California United States 92806
Clinical Trials Management Services, LLC - Thousand Oaks Thousand Oaks, California United States 91360
Velocity Clinical Research - La Mesa La Mesa, California United States 91942
Velocity Clinical Research - Banning Banning, California United States 92220
The James Cook University Hospital - Middlesbrough Middlesbrough, Cleveland United Kingdom TS4 3BW
Care Access Research - Aurora Aurora, CO United States 80012
University of Colorado Anschutz Medical Campus - Aurora Aurora, Colorado United States 80045
New England Research Associates - Bridgeport Bridgeport, Connecticut United States 06606
Emerson Clinical Research Institute LLC - Washington D.C. Washington, DC United States 20011
Indago Research and Health Center - Hialeah Hialeah, Florida United States 33012
Ideal Clinical Research - Pembroke Pembroke Pines, Florida United States 33026
Edward Jenner Research Group - Plantation Plantation, Florida United States 33317
Luna Research - Coral Gables Coral Gables, Florida United States 33134
Floridian Clinical Research - Miami Lakes Miami Lakes, Florida United States 33016
Precision Clinical Research - Sunrise Sunrise, Florida United States 33351
Spotlight Research Center LLC Miami, Florida United States 33176
Invictus Clinical Research Group Coconut Creek, Florida United States 33073
Herco Medical and Research Center - Coral Gables Coral Gables, Florida United States 33134
Emerald Coast OB/GYN Clinical Research Panama City, Florida United States 32405
GCP Research, Global Clinical Professionals St. Petersburg, Florida United States 33705
iResearch Atlanta - Decatur Decatur, Georgia United States 30030
Drug Studies America - ClinEdge - Marietta Marietta, Georgia United States 30060
One Health Research Clinic - Norcross Norcross, Georgia United States 30093
Tekton Research - Chamblee Chamblee, Georgia United States 30341
Velocity Boise Meridian, ID United States 86342
Clinical Research Prime - ClinEdge - PPDS Idaho Falls, Idaho United States 83404-5305
Affinity Health - Oak Brook Oak Brook, IL United States 60523
Heartland Research - Newton Newton, Kansas United States 67114
Johnson County Clinical Trials - Lenexa Lenexa, Kansas United States 66219
Alliance for Multispecialty Research - Lexington Lexington, Kentucky United States 40509
Velocity Clinical Research - Covington Metairie, Louisiana United States 70006
Skylight Health Research – Burlington Burlington, MA United States 01803
Centennial Medical Group - Elkridge Elkridge, Maryland United States 21075
Meridian Clinical Research - Rockville Rockville, Maryland United States 20854
DM Clinical Research - The Brook House Brookline, Massachusetts United States 02444-7113
ActiveMed Practices & Research - Methuen Methuen, Massachusetts United States 01844
DM Clinical Research – Detroit Road Southfield, MI United States 48076
Great Lakes Research Institute Southfield, MI United States 48075
Wayne State University C.S Mott Clinical Research Center - Detroit Detroit, Michigan United States 48201
Clinical Research Institute - Minneapolis Minneapolis, Minnesota United States 55402
MedPharmics - Gulfport Gulfport, Mississippi United States 39503
MediSync Clinical Research Hattiesburg Clinic - Petal Petal, Mississippi United States 39465
Boeson Research KAL - Kalispell Kalispell, Montana United States 59901-2158
Boeson Research GTF - Great Falls Great Falls, Montana United States 59405
Boeson Research MSO - Missoula Missoula, Montana United States 59804
Meridian Clinical Research - Hastings Hastings, Nebaska United States 68901
Quality Clinical Research - Omaha Omaha, Nebraska United States 68114
Meridian Clinical Research - Omaha Omaha, Nebraska United States 68114
Meridian Clinical Research - Norfolk Norfolk, Nebraska United States 68701
Be Well Clinical Studies - Lincoln Lincoln, Nebraska United States 68516
Meridian Clinical Research - Grand Island Grand Island, Nebraska United States 68803
Clinical Research Center Of Nevada Las Vegas , Nevada United States 89106
Med Clinic Research Partners - Irvington Irvington, New Jersey United States 07111
MedPharmics - Albuquerque Albuquerque, New Mexico United States 87102
Albuquerque Clinical Trials - Albuquerque Albequerque, New Mexico United States 87102
WellNow Urgent Care Clinical Research - East Amherst East Amherst, New York United States 14051
SUNY Upstate Medical Center Syracuse, New York United States 13210
Meridian Clinical Research - Endwell Binghamton, New York United States 13905
Rochester Clinical Research - Rochester Rochester, New York United States 14609
Monroe Biomedical Research - Venus St Monroe, North Carolina United States 28112
Carolina Institute for Clinical Research - Fayetteville Fayetteville, North Carolina United States 28303
Lucas Research - Morehead City Morehead City, North Carolina United States 28557
M3 Wake Research - Raleigh Raleigh, North Carolina United States 27612-8106
OnSite Clinical Solutions - Charlotte Charlotte, North Carolina United States 28277
Lillestol Research - Fargo Fargo, North Dakota United States 58104
Senders Pediatrics - South Euclid South Euclid, Ohio United States 44121
WellNow Urgent Care - Dayton Dayton, Ohio United States 45424
Meridian Clinical Research - Cincinnati Cincinnati, Ohio United States 45219
PriMed Physicians - Dayton Dayton, Ohio United States 45419
Aventiv Research - Columbus Columbus, Ohio United States 43213
CTI Clinical Research Center - Cincinnati Cincinnati, Ohio United States 45212
Lynn Health Science Institute - Oklahoma City Oklahoma City, Oklahoma United States 73112
Epic Medical Research - Chickasha Chickasha, Oklahoma United States 73018
Tekton Research - Yukon Yukon, Oklahoma United States 73099
Ottawa Hospital Ottawa, Ontario Canada K1H 8L6
Velocity Clinical Research Inc – PPDS Medford, Oregon United States 97504
UPMC University Center - Pittsburgh Pittsburgh, Pennsylvania United States 15213
Southampton General Hospital Southampton, Southampton United Kingdom SO16 6YD
Acellacare - Mount Pleasant Mount Pleasant, South Carolina United States 29464
Premier Family Physicians - Austin Austin, Texas United States 78735
ClinPoint Trials - Waxahachie Waxahachie, Texas United States 75165
Global Medical Research Dallas, Texas United States 75224
Crossroads Clinical Research - Victoria Victoria, Texas United States 77901
Synergy Group US - Missouri City Missouri City, Texas United States 77459
Gadolin Research - Beaumont Beaumont, Texas United States 77702
Helios Clinical Research - Keller Keller, Texas United States 76248
BRCR Medical Center Inc - McAllen McAllen, Texas United States 78503
DM Clinical Research - ERN - PPDS Tomball, Texas United States 77375
Diagnostics Research Group - San Antonio San Antonio, Texas United States 78229
New Horizon Medical Group - Houston Houston, Texas United States 77063
Village Health Partners Frisco Medical Village - Plano Plano, Texas United States 75024
REX Clinical Trials Beaumont, Texas United States 77701
Vilo Research Group - Houston Houston, Texas United States 77017
Tekton Research - Beaumont Beaumont, Texas United States 77706
Trio Clinical Trials Houston, Texas United States 77008
Epic Medical Research - Red Oak Red Oak, Texas United States 75154
Velocity Clinical Research - Cedar Park Cedar Park, Texas United States 78613
ANRC Research - El Paso El Paso, Texas United States 79936
UTMB Health Pediatric Primary Care - League City League City, Texas United States 77573
Tekton Research - Austin Austin, Texas United States 78745
Koncord Clinical Research McAllen, Texas United States 78577
Cedar Health Research - Irving Irving, Texas United States 75062
Clinical Trials of Texas - San Antonio San Antonio, Texas United States 78229
ACRC Trials - Inn Derm - Plano Plano, Texas United States 75025
Velocity Clinical Research - West Jordan West Jordan, Utah United States 84088
Foothill Family Clinic - Salt Lake City Salt Lake City, Utah United States 84121
Foothill Family Clinic - Salt Lake City Salt Lake City, Utah United States 84109
Granger Medical Clinic - Riverton Riverton, Utah United States 84096
Tanner Clinic - Layton Layton, Utah United States 84041-8803
David Ramstad Associates Research - Suffolk Suffolk, Virginia United States 23435-3763
Health Research of Hampton Roads - Newport News Newport News, Virginia United States 23606
Seattle Clinical Research Center Seattle, Washington United States 98105
Velocity Clinical Research - Spokane Spokane, Washington United States 99204
Rainier Clinical Research Center - Renton Renton, Washington United States 98057
University Of Wisconsin - Madison Madison, Wisconsin United States 53792
FAQ
Below are some frequently asked questions about the CMVictory Trial.