This trial has completed recruitment on this platform, and is no longer accepting new referrals.
The purpose of the RSVictory Trial is to assess the safety and immune response of an investigational vaccine, mRNA-1345, for RSV infection when given with or without an approved flu vaccine. RSV and the flu are both common respiratory viruses that infect the lungs and breathing passages. People most often associate RSV with the risk it brings to young children, but not many know the high risk it poses for older adults.
RSV symptoms can be like a cold, and may include runny nose, sore throat, cough, and headache. However, RSV can lead to serious conditions like pneumonia, especially for younger children and older adults. RSV is an increasingly recognized cause of major illness among older adults and adults with certain health conditions, especially those with heart and lung disease. Currently there is no approved vaccine for RSV.
The flu is estimated to cause 3 to 5 million cases of severe illness and up to 650,000 deaths each year. Current flu vaccinations rarely exceed 60% overall effectiveness.
mRNA-1345 is an investigational vaccine, based on mRNA technology.
Sites are located in the cities/states identified with the red pin:
Participation in this clinical trial lasts up to 6 months and includes up to 5 in-person visits and 4 telephone calls with the clinical trial staff.
Participants will be randomly assigned to one of three groups. Each participant will get two injections, one in each upper arm.
Participants will be asked to have up to 4 phone calls with the clinical trial doctor to monitor any symptoms. During these phone calls, the doctor and medical staff will check how you are feeling and ask for updates on your health.
Participants will be asked to use an eDiary app on their personal smartphone or a provided smartphone to report any symptoms you experience.
Insurance is not needed to join this clinical trial, and travel expenses will be reimbursed.