This trial is not actively recruiting.

This trial has completed recruitment on this platform, and is no longer accepting new referrals.

A vaccine trial for COVID-19

A study to test an investigational vaccine that may protect people from getting sick if they come into contact with the SARS-CoV-2 virus, which causes COVID-19; also known as coronavirus.

Trial ID: NCT04470427

Moderna’s Commitment to Diversity & Inclusion

Moderna is committed to researching a safe and effective vaccine that protects people from all backgrounds against COVID-19.

People from racial and ethnic minority groups are at even greater risk of getting sick and dying from COVID-19. Given that certain populations can respond differently to medical therapies, it is important that study volunteers from all races and ethnicities participate in the COVE Study to ensure the vaccine is safe and effective for everyone to use.

Moderna has proudly partnered with 99 clinical research sites across the US, and we actively collaborate with nonprofits, local community organizations, and faith and cultural leaders to address current and historical barriers, build trust, and raise awareness of this important clinical trial to communities at highest risk of COVID-19.

Trial Details

The mRNA-1273 vaccine is being developed to prevent COVID-19, the disease resulting from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection. Study volunteers will participate and be followed by medical staff for up to two years. The study doctor and medical staff will talk to you about additional medical support that you will receive if you experience COVID-19 symptoms at any time while in this clinical trial. Insurance is not needed to join this clinical trial, and compensation for your time will be available.

Estimated Enrollment

30,000 participants

Given that certain populations can respond differently to medical therapies, it is extremely important that this clinical trial include people from all races and ethnicities to ensure the vaccine is safe and effective for everyone to use.



Eligibility Criteria

Participants must:
  • Be 18 years of age and older
  • Have never tested positive for COVID-19
  • Have a greater chance of becoming infected with COVID-19. Examples include:
    • Living in crowded conditions such as shared housing
    • Working in close contact with the public or other workers including “essential work” settings: healthcare facilities, farms, factories, grocery stores, restaurants, daycares, and public safety/transportation
    • You have underlying medical conditions
    • You are 65 or older
Participants must not:
  • Have been in close contact with anyone that has tested positive for COVID-19 in the past month
  • Be pregnant or breastfeeding
  • Have participated in another trial in the past month

Commitments from you

What's Involved

The total length of trial participation is two years and includes seven visits to the study clinic and monthly phone calls from the study doctor.

You will need to travel to one of the 100 sites taking part in this clinical trial. Sites are located in:

Actively Recruiting

  • Dallas, Texas, United States
  • Salt Lake City, Utah, United States
  • Charlotte, North Carolina, United States
  • Melbourne, Florida, United States
  • Philadelphia, Pennsylvania, United States
  • New York, New York, United States
  • Jacksonville, Florida, United States
  • Glendale, Arizona, United States
  • Cincinnati, Ohio, United States
  • Birmingham, Alabama, United States
  • Winston-Salem, North Carolina, United States
  • Medford, Oregon, United States
  • Dakota Dunes, South Dakota, United States
  • Oklahoma City, Oklahoma, United States
  • Mount Pleasant, South Carolina, United States
  • Phoenix, Arizona, United States
  • Sacramento, California, United States
  • Colorado Springs, Colorado, United States
  • Washington, District of Columbia, United States
  • La Mesa, California, United States
  • Hollywood, Florida, United States
  • Stockbridge, Georgia, United States
  • Galveston, Texas, United States
  • Norfolk, Nebraska, United States
  • Newark, New Jersey, United States
  • Aurora, Colorado, United States
  • Orlando, Florida, United States
  • Greenville, South Carolina, United States
  • Newton, Kansas, United States
  • Atlanta, Georgia, United States
  • Banning, California, United States
  • Nashville, Tennessee, United States
  • Austin, Texas, United States
  • Tucson, Arizona, United States
  • Redding, California, United States
  • Chattanooga, Tennessee, United States
  • Knoxville, Tennessee, United States
  • Anderson, South Carolina, United States
  • Lenexa, Kansas, United States
  • Tomball, Texas, United States
  • Decatur, Georgia, United States
  • Saint Louis, Missouri, United States
  • Hackensack, New Jersey, United States
  • Chandler, Arizona, United States
  • Baton Rouge, Louisiana, United States
  • Peoria, Arizona, United States
  • Miami, Florida, United States
  • McAllen, Texas, United States
  • Los Angeles, California, United States
  • Omaha, Nebraska, United States
  • Chicago, Illinois, United States
  • Wichita, Kansas, United States
  • Houston, Texas, United States
  • Fort Worth, Texas, United States
  • Binghamton, New York, United States
  • Rockville, Maryland, United States
  • Baltimore, Maryland, United States
  • Chapel Hill, North Carolina, United States
  • Petal, Mississippi, United States
  • West Palm Beach, Florida, United States
  • Grand Island, Nebraska, United States
  • Spartanburg, South Carolina, United States
  • Metairie, Louisiana, United States
  • Boston, Massachusetts, United States
  • Little Rock, Arkansas, United States
  • Laredo, Texas, United States

Not yet Recruiting

  • (Awaiting confirmation) San Diego, California, United States
  • (Awaiting confirmation) La Jolla, California, United States
  • (Awaiting confirmation) San Angelo, Texas, United States
  • (Awaiting confirmation) Cleveland, Ohio, United States
  • (Awaiting confirmation) Las Vegas, Nevada, United States
  • (On hold) Austin, Texas, United States
  • (Awaiting confirmation) Savannah, Georgia, United States
  • (Awaiting confirmation) Pittsburgh, Pennsylvania, United States
  • (Awaiting confirmation) Chicago, Illinois, United States
  • (Awaiting confirmation) Detroit, Michigan, United States
  • (On hold) Wilmington, North Carolina, United States
  • (On hold) DeLand, Florida, United States
  • (On hold) Miami, Florida, United States
  • (Awaiting confirmation) Fayetteville, North Carolina, United States
  • (Awaiting confirmation) Cedar Park, Texas, United States
  • (Awaiting confirmation) Raleigh, North Carolina, United States
  • (Awaiting confirmation) Houston, Texas, United States
  • (Awaiting confirmation) San Antonio, Texas, United States
  • (Awaiting confirmation) Rockville, Maryland, United States

Potential Benefits

The study vaccine is investigational as effectiveness and safety have not been established. There is no guarantee that the study vaccine will become commercially available.

Potential Risks

Frequently Asked Questions (FAQ)