A vaccine trial for COVID-19

COVID-19 has become a global health threat, and the need for a safe and effective vaccine is critical.

Trial ID: 2019nCov-301

Novavax Commitment to Diversity & Inclusion

This clinical trial is testing whether the investigational NVX-CoV2373 vaccine candidate will prevent COVID-19

With over 100 study sites, we are looking for up to 30,000 participants from various backgrounds to take part in this clinical trial. We have partnered with study sites who are dedicated to reaching individuals who by virtue of their life circumstances (i.e., living or working conditions) are considered at substantial risk of exposure to and infection with COVID-19. Within this high-risk population of individuals, prioritization will be given to the enrollment of important groups that have been disproportionately impacted by COVID-19. These groups include members of the Black/African American, LatinX or Native American communities, people living with medical conditions commonly associated with complications arising from COVID-19 disease (e.g., obesity, chronic kidney or lung disease, cardiovascular disease and Type 2 diabetes), and the elderly.

Trial Details

This COVID-19 clinical trial is testing whether the investigational NVX-CoV2373 vaccine candidate will prevent COVID-19. It will compare this vaccine with a placebo, a substance that contains no active medication.

Participants who qualify for the study will receive:

  • Study-related medical tests throughout the clinical trial
  • The study vaccine or placebo
  • Study-related monitoring of health and follow-up care

Estimated Enrollment

30,000 participants

Given that certain populations can respond differently to medical therapies, it is extremely important that this clinical trial include people from all races and ethnicities to ensure the vaccine is safe and effective for everyone to use.



Eligibility Criteria

Participants must:
  • Be 18 years of age and older
  • Have never tested positive for COVID-19
  • Have a greater risk of becoming infected with COVID-19. Examples include:
    • Represent a racial and ethnic group that has been greatly impacted by the pandemic such as African American, LatinX, Native American
    • Live in crowded conditions such as shared housing
    • Are at greater risk of becoming infected with the virus that causes and/or developing more severe disease
    • Work in close contact with the public or other workers including “essential work” settings: healthcare facilities, farms, factories, grocery stores, restaurants, daycares, and public safety/transportation
    • Have underlying medical conditions
    • Are 65 or older
Participants are not eligible if they:
  • Have previously tested positive for COVID-19
  • Are pregnant or breastfeeding
  • Have participated in another clinical trial in the past month

Check Your Eligibility

We’ll check to see if you are eligible by asking you some questions.

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What's Involved

Participation for this clinical trial is divded into 3 periods:

You will be randomly assigned (by chance) to receive either the study vaccine or placebo. A placebo does not contain any active ingredient. Neither you nor the study doctor will know which group you are in or which injection you receive. Each participant will receive 2 injections, 21 days apart.

You will need to travel to one of up to 114 sites in the U.S. taking part in this clinical trial. U.S. sites are located in:

Actively Recruiting

  • La Mesa, California, US
  • Hallandale Beach, Florida, US
  • Colorado Springs, Colorado, US
  • Pomona, California, US
  • Little Rock, Arkansas, US
  • Anaheim, California, US
  • Chula Vista, California, US
  • Detroit, Michigan, US
  • Norfolk, Nebraska, US
  • Meridian, Idaho, US
  • Fayetteville, North Carolina, US
  • Valparaiso, Indiana, US
  • Atlanta, Georgia, US
  • Evansville, Indiana, US
  • Chicago, Illinois, US
  • Lenexa, Kansas, US
  • Metairie, Louisiana, US
  • Iowa City, Iowa, US
  • Omaha, Nebraska, US
  • Tampa, Florida, US
  • Henderson, Nevada, US
  • Sioux City, Iowa, US
  • Bristol, Tennessee, US
  • San Antonio, Texas, US
  • Houston, Texas, US
  • Warwick, Rhode Island, US
  • Memphis, Tennessee, US
  • McAllen, Texas, US
  • Chattanooga, Tennessee, US
  • Cincinnati, Ohio, US
  • Medford, Oregon, US
  • Plano, Texas, US
  • Cleveland, Ohio, US
  • Anderson, South Carolina, US
  • Miami, Florida, US
  • Stockbridge, Georgia, US
  • Lakeland, Florida, US
  • Richfield, Minnesota, US
  • Los Angeles, California, US
  • Gainesville, Florida, US
  • Vestavia Hills, Alabama, US
  • Sacramento, California, US
  • Columbia, Missouri, US
  • Cheney, Washington, US
  • Fort Worth, Texas, US
  • Vista, California, US
  • Jacksonville, Florida, US
  • Charleston, South Carolina, US
  • Austin, Texas, US
  • Tempe, Arizona, US
  • Orlando, Florida, US
  • West Palm Beach, Florida, US
  • Oklahoma City, Oklahoma, US
  • Gulfport, Mississippi, US
  • Los Alamitos, California, US
  • West Jordan, Utah, US
  • Banning, California, US
  • Durham, North Carolina, US
  • Newport News, Virginia, US
  • Baton Rouge, Louisiana, US
  • Columbus, Georgia, US
  • Saint Louis, Missouri, US
  • North Hollywood, California, US
  • Pinellas Park, Florida, US
  • Rochester, New York, US
  • San Diego, California, US
  • Chapel Hill, North Carolina, US
  • Raleigh, North Carolina, US
  • Hollywood, Florida, US
  • DeLand, Florida, US
  • Baltimore, Maryland, US
  • The Villages, Florida, US
  • Akron, Ohio, US

Currently Inactive

  • (Not yet recruiting) Miami, Florida, US
  • (Not yet recruiting) Chinle, Arizona, US
  • (Active not recruiting) Woodland, California, US
  • (Not yet recruiting) Sacramento, California, US
  • (Not yet recruiting) Atlanta, Georgia, US
  • (Not yet recruiting) Mokena, Illinois, US
  • (Not yet recruiting) Shreveport, Louisiana, US
  • (Not yet recruiting) Ann Arbor, Michigan, US
  • (Not yet recruiting) Rocky Mount, North Carolina, US
  • (Not yet recruiting) Eagle Butte, South Dakota, US
  • (Not yet recruiting) Knoxville, Tennessee, US
  • (Not yet recruiting) Nashville, Tennessee, US
  • (Active not recruiting) Phoenix, Arizona, US
  • (Not yet recruiting) Minneapolis, Minnesota, US
  • (Active not recruiting) Commack, New York, US
  • (Active not recruiting) San Antonio, Texas, US
  • (Active not recruiting) Boston, Massachusetts, US
  • (Not yet recruiting) Washington, District of Columbia, US
  • (Not yet recruiting) Wilmington, North Carolina, US
  • (Active not recruiting) Aurora, Colorado, US
  • (Active not recruiting) New York, New York, US

Frequently Asked Questions (FAQ)

Check Your Eligibility

We’ll check to see if you are eligible by asking you some questions.

Get Started